Flipping ATP to AMPlify Kinase Functions

Functions arising by coin flipping

We repeatedly toss a biased coin where the probability is p of observing “heads”. The probability of a certain event can be regarded as a function of p. L. Lovász asked for a characterization of the functions occurring as the probability of some “reasonable” event. We state this problem in precise terms by introducing the concept of an “observable” event. Our main theorem states that a function...

Lossy Functions Do Not Amplify Well

We consider the problem of amplifying the “lossiness” of functions. We say that an oracle circuit C∗ : {0, 1} → {0, 1}∗ amplifies relative lossiness from `/n to L/m if for every function f : {0, 1} → {0, 1} it holds that 1. If f is injective then so is C . 2. If f has image size of at most 2n−`, then C has image size at most 2m−L. The question is whether such C∗ exists for L/m `/n. This problem...

Acidify to amplify growth performance

The recent complete ban on the use of the antibiotic growth promoting substances by the EU and partly in several other countries worldwide urged nutritionists and animal scientists to seek for alternatives. The use of organic acids in poultry and pig nutrition appears to be an interesting solution that can enhance the eff ect of other feed additives, as well. In combination with other substance...

Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor

ATP metabolism in pyruvate kinase deficient erythrocytes.

With the technical assistance of Wilma J. Hudson T HE NIATURE HUMAN ERYTHROCYTE, without a nucleus, mitochondria, or endoplasmic reticulum, has limited metabolic capabilities. It depends upon anerobic glycolysis for biochemical energy . This leaves the erythrocyte little ability to compensate for metabolic defects. Pyruvate kinase ( PK ) deficiency is one of an increasing list of red cell enzym...